What should be done if a dose of clozapine is missed?

When a dose of clozapine is missed, it is crucial to manage the situation carefully due to the unique pharmacological profile of the medication. If a patient misses a dose, the recommended approach typically involves consulting with a healthcare provider to determine the best course of action, given the specific circumstances surrounding the missed dose.

In certain cases, re-titrating the dose may be necessary. Clozapine has a risk of relapse in symptoms if there are interruptions in the dosing regimen. Rapid re-titration helps ensure that the plasma levels of the drug are maintained within the therapeutic range, thereby minimizing potential withdrawal symptoms and ensuring the effectiveness of the treatment.

In clinical practice, missed doses must be addressed thoughtfully considering the patient's history and dosage regimen. Following established guidelines for clozapine management is important to maintain therapeutic stability and minimize risks associated with abrupt changes in medication. Consulting with a physician can provide tailored recommendations based on the patient's current condition.