What medication should be avoided in patients with head injuries?

In patients with head injuries, the use of NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) is discouraged due to their potential to interfere with blood clotting. One of the primary concerns in head injury cases is the risk of intracranial bleeding. NSAIDs work by inhibiting enzymes involved in the inflammatory process, but they also have an antiplatelet effect, which can increase the risk of bleeding if there is damage to blood vessels within or surrounding the brain.

In contrast, acetaminophen is generally considered safe for pain relief in these patients as it does not affect platelet function. Opioids, while they carry their own risks, do not have the same effect on bleeding and may be used cautiously under medical supervision. Antidepressants also do not present an intrinsic risk related to bleeding in the context of head injuries and may be prescribed for comorbid conditions such as anxiety or depression.