What is a common side effect of prednisone?

Fluid retention is a common side effect of prednisone due to its effects on salt and water balance in the body. Prednisone acts as a corticosteroid, which can lead to increased sodium retention and potassium excretion. This can result in swelling and puffiness, particularly in the face and extremities, as the body retains excess fluid. This side effect is particularly significant in patients taking higher doses or long-term therapy with prednisone, highlighting the need for monitoring and managing any associated complications. Conditions like hypertension and heart failure can be exacerbated by fluid retention, therefore awareness of this effect is important for nursing practice and patient care.