What is a common adverse effect of long acting nitrates?

Long-acting nitrates, commonly used in the management of angina and other cardiovascular conditions, can lead to a variety of side effects due to their mechanism of action. One of the most frequently reported adverse effects is headaches. This occurs because nitrates cause vasodilation, leading to increased blood flow in the cerebral vessels, which can trigger headache sensations.

While other side effects may include nausea, fatigue, and palpitations, headaches are particularly prevalent among patients taking long-acting nitrates. Many patients may initially experience these headaches, but they often diminish over time as the body adjusts to the medication. Understanding this common reaction helps healthcare providers prepare patients for potential side effects and manage them effectively.