What effect does prednisone have on blood pressure?

Prednisone is a corticosteroid that can increase blood pressure, particularly when used at higher doses or over an extended period. This effect is primarily due to its ability to cause sodium retention and potassium loss, which can lead to fluid retention and subsequently increase blood volume. In addition, prednisone can influence other hormonal systems that regulate blood pressure, contributing to its hypertensive effects. Patients on prednisone may need monitoring for changes in blood pressure, especially if they are also taking medications that affect blood pressure or have existing hypertension. Therefore, the mechanism by which prednisone raises blood pressure is well-documented and important for healthcare providers to consider in patient management.